Vivas Week 1

1. Which factors determine the volume of distribution of a drug?

Describe the volume of distribution of the tricyclic anti-depressants. How does this influence their toxicity?

What therapies for tricyclic toxicity might reduce their tissue distribution?

2. Describe the cellular changes in necrosis

What are the patterns in tissue necrosis?

3. In the context of drug-receptor interactions, what is the difference between a full agonist and a partial agonist?

Under what circumstances can a partial agonist act as an antagonist?

4. What is an antagonist?

What is the difference between a competitive and a non-competitive antagonist?

5. Can you define potency?

Can you define efficacy?

Show the difference between efficacy and potency by drawing graded dose-response curves

Compare the potency of morphine to fentanyl

6. Describe the sequence of events that occur in reversible ischaemic cellular injury

List the morphological changes of irreversible cellular injury

Describe reperfusion injury