MCQs Week 2 Loading... 1. Atrophy is characterised by Lipoxin targeting proteins for degradation in lysosomesReduction of residual bodiesIncreased cell function in the early stagesMore autophagic vacuolesQuestion 1 of 15 Loading... 2. Which of the following is a phase one reaction? ReductionAcetylationGlucoronidationMethylationQuestion 2 of 15 Loading... 3. Regarding cellular atrophy Atrophy refers to the reduced size of an organ or tissue with a normal number of cells due to a decrease in cell sizeDegradation of proteins occurs mainly by the ubiquitin-protease pathwayAtrophy of disuse is an example of physiologic atrophyThe cellular changes in atrophy vary significantly depending on it's causeQuestion 3 of 15 Loading... 4. Hypertrophy Is not a feature of stressed non-dividing cellsOccurs only in response to cell stressIn muscle cells leads to increased numbers of myofilamentsAndrogen stimulation leading to an enlarged prostate is an example of pathological hypertrophyQuestion 4 of 15 Loading... 5. What is the half life of a drug with a Vd 700L/70kg and a clearance of 49L/hr/70kg? 7 hours10 hours12.5 hours15 hoursQuestion 5 of 15 Loading... 6. Regarding bioavailability of a drug Is less than 20% for drugs given by the transdermal routePR and PO administration are both enteral and thus have equivalent bioavailabilityMetabolism by the liver is the sole mechanism for first pass eliminationSublingual absorption provides direct access to systemic veinsQuestion 6 of 15 Loading... 7. Volume of distribution equals Concentration given / Plasma concentrationTotal amount of drug / Plasma concentrationUrinary drug concentration / Plasma concentrationTotal amount of drug / Urine concentrationQuestion 7 of 15 Loading... 8. In aqueous diffusion of a drug Diffusion is inversely proportional to areaDiffusion is proportional to the permeability co-efficientDiffusion is inversely proportional to C1 - C2Diffusion is proportional to thicknessQuestion 8 of 15 Loading... 9. Which of the following statements regarding the dorsal scapular nerve is correct? It is a branch of C6 from the cervical plexusIt passes through scalenus mediusIt usually gives a branch to serratus anteriorIt does not supply levator scapulaeQuestion 9 of 15 Loading... 10. A 40yr male suffered a whiplash injury to his neck and now complains of pan along the lateral aspect of his left forearm, there is weakness of his left biceps muscle. Which is the most likely cause? Prolapsed 4th cervical disc impinging on C4 rootProlapsed 3rd cervical disc impinging on C4 rootProlapsed 5th cervical disc impinging on C5 rootProlapsed 5th cervical disc impinging on C6 rootQuestion 10 of 15 Loading... 11. When considering the blood supply of the spinal cord Is from a single anterior and posterior arteryAnteriorly is from the anterior spinal artery derived from the right brachiocephalic trunkLies in the subdural spaceThe roots of the spinal cord receives important contributions from radicular arteriesQuestion 11 of 15 Loading... 12. Regarding lymphocytes in humans Activated T lymphocytes form plasma cellsT lymphocytes present antigens to activate B lymphocytesB lymphocytes require T lymphocyte contact to produce antibodies fullySomatic mutations account for huge diversity in immunoglobulinsQuestion 12 of 15 Loading... 13. Cellular calcification Cannot occur in the presence of hypocalcaemiaAtheroma is an example of metastatic calcificationCan be associated with sarcoidosisSpares the gastric mucosaQuestion 13 of 15 Loading... 14. What is the half life of a drug given a Vd of 2000L/70kg and a clearance of 20L/hr/70kg? 100hours70hours10hours7hoursQuestion 14 of 15 Loading... 15. Regarding the sodium-potassium pump Moves three Na in and two K out of the cell for each molecule of ATP hyrdolysedActivity is enhanced by ouabain and digitalis glycosidesIs saturated if the Na level increasesThyroid hormone and aldosterone act to increase the number of pumpsQuestion 15 of 15 Loading...
